Guts and Glory is about ordinary people competing in extraordinary challenges of life and death! Several possible game modes are planned, but the first is a "survival racing experience." Players will select from a wide variety of vehicles, including realistic bicycles, poorly built cars, and rocket-powered homemade contraptions. They’ll race to the finish line dodging all sorts of hazards, including sawblade windmills, giant wrecking balls, medieval cannons and crazy turrets. Each vehicle is completely physics-driven, with 100% ragdoll riders, realtime dismemberment, and vehicle damage. This means that every turn, every crash, and every death is unique—and often results in hilarious scenarios! 
Jacksepticeye first started playing the pre-alpha of the game, with the characters John and Jimmy (who he refers to as Billy and Bobby) only being available to play with. Eventually he ends up gaining access to the characters Earl and The Yang Family.